ASIA
ASIA Autoimmune / inflammatory syndrome, induced by adjuvants.
ASIA or Shoenfeld's syndrome: a new autoimmune syndrome? 2010 >>
Criteria suggested by Shoenfeld for ASIA diagnosis
Criteria suggested by Shoenfeld for ASIA diagnosis
Major criteria
- Exposure to an external stimuli (infection, vaccin, silicone, adjuvant prior to clinical manifestions
- Appearance of ons of the clinical manifestions:
- myalgia, myositis, of muscular weakness
- arthralgia and / of arthirtis
- chronical fatigue, non-restful, sleep of sleep disturbances
- neurological manifestations (especially those associated with demyelization)
- cognitive alterations, loss of memory
- fever, dry mouth
- removal of the initiating agent induces improvement
- typical biopsy of the involved organs
Minor criteria
- Appearance of autoantibodies derectes anganist the suspected adjuvant
- Other clinical manifestations (e.g. irritable blowl syndome)
- Specific HLA (e.g. HLA, DRB1, HLA, DQB1)
- Initiation of an autoimmune illness (e.g. multiple sclerosis, systemic sclerosis)